Sinclair Method Studies
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.

The Sinclair Method (TSM) offers a compassionate, scientifically-backed alternative to traditional abstinence-based approaches for treating Alcohol Use Disorder (AUD). By utilising the opioid antagonist naltrexone, TSM enables individuals to gradually reduce their alcohol consumption, leading to significant benefits both physically and emotionally.
The Sunday Reset
Every Sunday, we share a 2-minute insight into the logic of the Sinclair Method.
Join thousands of others for our weekly newsletter and change how you see the problem,
because when you change the way you look at things, the things you look at change.
… There’s a reason we’re called Rethink Drink!
